NADPH oxidase-IN-1 is an orally active inhibitor of NADPH oxidase (Nox), specifically targeting Nox2 and Nox4 with IC50 values of 1.9 μM and 2.47 μM, respectively. This compound is notable for its ability to penetrate the blood-brain barrier, making it relevant for studies involving neuronal inflammation. NADPH oxidase-IN-1 effectively suppresses the production of pro-inflammatory cytokines and inhibits LPS-mediated microglial migration, demonstrating promising in vivo efficacy for potential therapeutic applications in neuroinflammatory conditions.
NADPH oxidase-IN-1 is an orally active inhibitor of NADPH oxidase (Nox), specifically targeting Nox2 and Nox4 with IC50 values of 1.9 μM and 2.47 μM, respectively. This compound is notable for its ability to penetrate the blood-brain barrier, making it relevant for studies involving neuronal inflammation. NADPH oxidase-IN-1 effectively suppresses the production of pro-inflammatory cytokines and inhibits LPS-mediated microglial migration, demonstrating promising in vivo efficacy for potential therapeutic applications in neuroinflammatory conditions.
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