Naldemedine is a potent μ-opioid receptor antagonist, designed for the treatment of opioid-induced constipation (OIC). It exhibits high binding affinities for μ-, δ-, and κ-opioid receptors, with Ki values of 0.34, 0.43, and 0.94 nM, respectively, and shows significant antagonist activity with IC50 values of 25.57, 7.09, and 16.1 nM. Additionally, Naldemedine is predicted to interact with 3CLpro, an enzyme encoded by the SARS-CoV-2 genome, making it a valuable tool for various research applications in opioid receptor mechanisms and viral interactions.
Naldemedine is a potent μ-opioid receptor antagonist, designed for the treatment of opioid-induced constipation (OIC). It exhibits high binding affinities for μ-, δ-, and κ-opioid receptors, with Ki values of 0.34, 0.43, and 0.94 nM, respectively, and shows significant antagonist activity with IC50 values of 25.57, 7.09, and 16.1 nM. Additionally, Naldemedine is predicted to interact with 3CLpro, an enzyme encoded by the SARS-CoV-2 genome, making it a valuable tool for various research applications in opioid receptor mechanisms and viral interactions.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
