Nampt Activator-3 is a potent NAD+ biosynthesis enhancer targeting nicotinamide phosphoribosyltransferase (NAMPT). With an EC50 of 2.6 μM and a KD of 132 nM, it effectively protects cultured cells from FK866-mediated toxicity. Additionally, Nampt Activator-3 demonstrates substantial neuroprotective effects in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN), indicating its potential applicability in neuroprotection research and therapeutic interventions.
Nampt Activator-3 is a potent NAD+ biosynthesis enhancer targeting nicotinamide phosphoribosyltransferase (NAMPT). With an EC50 of 2.6 μM and a KD of 132 nM, it effectively protects cultured cells from FK866-mediated toxicity. Additionally, Nampt Activator-3 demonstrates substantial neuroprotective effects in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN), indicating its potential applicability in neuroprotection research and therapeutic interventions.
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