Nampt activator-4 is a potent activator of nicotinamide phosphoribosyltransferase (NAMPT), exhibiting an EC50 of 0.058 μM in human cells and a binding affinity (Ka) of 0.08538 μM. By binding to the rear channel of NAMPT, it enhances enzyme activity and counteracts feedback inhibition caused by nicotinamide and NAD+, leading to increased cellular levels of nicotinamide adenine dinucleotide (NAD+). Nampt activator-4 can effectively shift the concentration-response curve of NAMPT inhibitors, making it a valuable tool for research into type 2 diabetes and metabolic regulation. Its stability in liver microsomes and impact on cytochrome P450 activity (CYP2D6 and CYP3A4) further support its potential utility in pharmacological studies.
Nampt activator-4 is a potent activator of nicotinamide phosphoribosyltransferase (NAMPT), exhibiting an EC50 of 0.058 μM in human cells and a binding affinity (Ka) of 0.08538 μM. By binding to the rear channel of NAMPT, it enhances enzyme activity and counteracts feedback inhibition caused by nicotinamide and NAD+, leading to increased cellular levels of nicotinamide adenine dinucleotide (NAD+). Nampt activator-4 can effectively shift the concentration-response curve of NAMPT inhibitors, making it a valuable tool for research into type 2 diabetes and metabolic regulation. Its stability in liver microsomes and impact on cytochrome P450 activity (CYP2D6 and CYP3A4) further support its potential utility in pharmacological studies.
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