NAMPT activator-6 is a potent activator of nicotinamide adenine monophosphate (NAMPT), playing a crucial role in the regulation of NAD+ biosynthesis. This compound facilitates reversible control over NAMPT and NAD+ levels through light-mediated techniques, enabling the development of photoswitchable proteolysis-targeting chimeras (PS-PROTACs). Research applications include modulation of NAMPT and NAD+ in vivo, offering potential for enhanced antitumor activity while minimizing the side effects associated with traditional inhibitors.
NAMPT activator-6 is a potent activator of nicotinamide adenine monophosphate (NAMPT), playing a crucial role in the regulation of NAD+ biosynthesis. This compound facilitates reversible control over NAMPT and NAD+ levels through light-mediated techniques, enabling the development of photoswitchable proteolysis-targeting chimeras (PS-PROTACs). Research applications include modulation of NAMPT and NAD+ in vivo, offering potential for enhanced antitumor activity while minimizing the side effects associated with traditional inhibitors.
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