Nebentan potassium (YM598) is a selective, orally active non-peptide antagonist of the endothelin ETA receptor. It demonstrates significant inhibition of [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptors, with Kis of 0.697 nM and 569 nM, respectively. This compound has shown potential in ameliorating the progression of cor pulmonale and myocardial infarction in vivo, making it valuable for cardiovascular research applications.
Nebentan potassium (YM598) is a selective, orally active non-peptide antagonist of the endothelin ETA receptor. It demonstrates significant inhibition of [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptors, with Kis of 0.697 nM and 569 nM, respectively. This compound has shown potential in ameliorating the progression of cor pulmonale and myocardial infarction in vivo, making it valuable for cardiovascular research applications.
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