Necrostatin-1

Catalog No.: A11973

RIPK1 inhibitor

Necrostatin-1

Necrostatin-1 Chemical Structure

CAS NO. 4311-88-0

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).

Availability: In stock

Package Price Qty
10 mg

Regular Price: $50.00

Special Price $45.00

25 mg

Regular Price: $90.00

Special Price $81.00

50 mg

Regular Price: $150.00

Special Price $135.00

10mM * 1mL in DMSO

Regular Price: $50.00

Special Price $45.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).
Targets
RIP1 (293T cells)
490 nM(EC50)
In vitro DMSO 52 mg/mL (200.51 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.56 mL 192.8 mL 385.61 mL
0.5 mM 7.71 mL 38.56 mL 77.12 mL
1 mM 3.86 mL 19.28 mL 38.56 mL
5 mM 0.77 mL 3.86 mL 7.71 mL

*The above data is based on the productmolecular weight 259.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11973
Actions Inhibitor
M. Wt 259.33
Formula C13H13N3OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 4311-88-0
Synonyms N/A
SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32

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