Necrostatin-1

Catalog No.: A11973

RIPK1 inhibitor

Necrostatin-1

Necrostatin-1 Chemical Structure

CAS NO. 4311-88-0

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).

Availability: In stock

Package Price Qty
10 mg
$50.00
25 mg
$90.00
50 mg
$150.00
10mM * 1mL in DMSO
$50.00
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Biological Activity

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).
Targets
RIP1 (293T cells)
490 nM(EC50)
In vitro (25°C) DMSO Warmed: 43 mg/mL (165.81 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+45% PEG 300+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.56 mL 192.8 mL 385.61 mL
0.5 mM 7.71 mL 38.56 mL 77.12 mL
1 mM 3.86 mL 19.28 mL 38.56 mL
5 mM 0.77 mL 3.86 mL 7.71 mL

*The above data is based on the productmolecular weight 259.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11973
Actions Inhibitor
CAS No. 4311-88-0
Formula C13H13N3OS
M. Wt 259.33
Purity >98%
SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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