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Nepicastat HCl

DBH inhibitor

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Catalog No. A11172

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Nepicastat hydrochloride 5mg A11172-5
Nepicastat hydrochloride 10mg A11172-10
Nepicastat hydrochloride 50mg A11172-50
Nepicastat hydrochloride 100mg A11172-100
Nepicastat HCl 10mM * 1mL in DMSO A11172-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Nepicastat hydrochloride is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

Nepicastat HCl

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Chemical Information

Catalog Num A11172
Actions Inhibitor
M. Wt 331.81
Formula C14H15F2N3S.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 170151-24-3
Synonyms RS-25560-197, SYN117
SMILES C1CC2=C(C=C(C=C2C[[email protected]]1N3C(=CNC3=S)CN)F)F.Cl

Biological Activity


Nepicastat hydrochloride is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

Bovine dopamine-beta-hydroxylase Human dopamine-beta-hydroxylase
8.5 nM9 nM


Solubility (25°C)* In vitro DMSO 66 mg/mL (198.9 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.14 mL 150.69 mL 301.38mL
0.5 mM 6.03 mL 30.14 mL 60.28 mL
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL

*The above data is based on the productmolecular weight 331.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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