NH2-PEG3-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker that incorporates a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. This compound is designed to enhance payload delivery by undergoing cleavage by cellular proteases, facilitating the release of the drug inside the target cells. The primary amine allows for versatile functionalization through reactions with carboxylic acids, reductive aminations, and various advanced coupling techniques, making it suitable for applications in drug development and targeted therapies.
NH2-PEG3-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker that incorporates a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. This compound is designed to enhance payload delivery by undergoing cleavage by cellular proteases, facilitating the release of the drug inside the target cells. The primary amine allows for versatile functionalization through reactions with carboxylic acids, reductive aminations, and various advanced coupling techniques, making it suitable for applications in drug development and targeted therapies.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
