NH2-UAMC1110 is an aminobutoxy derivative of the fibroblast activation protein (FAP) inhibitor UAMC1110, functioning as a precursor for the synthesis of FAP-targeted radiotracers. This compound is integral in producing the radiotracer FAPI-QS, known for its high tumor selectivity and dose-response, facilitating tumor diagnosis. NH2-UAMC1110 features an active amino group, allowing for covalent bonding with various molecules including bifunctional chelators like DOTA and DATA5m. It specifically binds to the FAP active site, inhibiting its serine protease activity, thereby blocking FAP-mediated tissue remodeling. Suitable for diagnostic imaging of tumors expressing FAP, NH2-UAMC1110 serves as a valuable tool in the study of FAP-related diseases such as fibrosis and arthritis.
NH2-UAMC1110 is an aminobutoxy derivative of the fibroblast activation protein (FAP) inhibitor UAMC1110, functioning as a precursor for the synthesis of FAP-targeted radiotracers. This compound is integral in producing the radiotracer FAPI-QS, known for its high tumor selectivity and dose-response, facilitating tumor diagnosis. NH2-UAMC1110 features an active amino group, allowing for covalent bonding with various molecules including bifunctional chelators like DOTA and DATA5m. It specifically binds to the FAP active site, inhibiting its serine protease activity, thereby blocking FAP-mediated tissue remodeling. Suitable for diagnostic imaging of tumors expressing FAP, NH2-UAMC1110 serves as a valuable tool in the study of FAP-related diseases such as fibrosis and arthritis.
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