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$0.00 - Kopa P, .et al. Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells, Mol Biol Rep, 2019, Oct 3 PMID: 31583565
- Macieja A, .et al. Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors, Mol Biol Rep, 2019, Apr 24 PMID: 31020489
Biological Activity
NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.14 mL | 125.69 mL | 251.38 mL |
| 0.5 mM | 5.03 mL | 25.14 mL | 50.28 mL |
| 1 mM | 2.51 mL | 12.57 mL | 25.14 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.03 mL |
*The above data is based on the productmolecular weight 397.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13993 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 208237-49-4 |
| Formula | C22H20ClNO4 |
| M. Wt | 397.8 |
| Purity | >98% |
| Synonyms | NK-314, NK 314 |
| SMILES | COC1=C(C2=C3CCC[N+]3=C4C5C=C6C(=CC5C=CC4=C2C=C1)OCO6)O.[Cl-] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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