NK314

Catalog No.: A13993

Topoisomerase II inhibitor

NK314

NK314 Chemical Structure

CAS NO. 208237-49-4

NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes.

Availability: Out of stock

Package Price
5 mg
$220.00
10 mg
$400.00
25 mg
$900.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Kopa P, .et al. Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells, Mol Biol Rep, 2019, Oct 3 PMID: 31583565
  • Macieja A, .et al. Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors, Mol Biol Rep, 2019, Apr 24 PMID: 31020489

Biological Activity

NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.14 mL 125.69 mL 251.38 mL
0.5 mM 5.03 mL 25.14 mL 50.28 mL
1 mM 2.51 mL 12.57 mL 25.14 mL
5 mM 0.5 mL 2.51 mL 5.03 mL

*The above data is based on the productmolecular weight 397.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13993
Actions Inhibitor
CAS No. 208237-49-4
Formula C22H20ClNO4
M. Wt 397.8
Purity >98%
Synonyms NK-314, NK 314
SMILES COC1=C(C2=C3CCC[N+]3=C4C5C=C6C(=CC5C=CC4=C2C=C1)OCO6)O.[Cl-]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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