NMT-IN-8 is a potent and selective inhibitor of N-myristoyl transferase (NMT), exhibiting an IC50 value of less than 10 nM. It effectively disrupts the catalyzed protein N-myristoylation by binding to the peptide binding pocket of NMT, thereby influencing critical biological pathways including protein trafficking, signal transduction, and viral replication. This compound is particularly relevant for research applications in oncology, such as MYC-addicted cancers and B-cell lymphoma, as well as in the study of infectious diseases, including malaria, HIV, and rhinovirus infections.
NMT-IN-8 is a potent and selective inhibitor of N-myristoyl transferase (NMT), exhibiting an IC50 value of less than 10 nM. It effectively disrupts the catalyzed protein N-myristoylation by binding to the peptide binding pocket of NMT, thereby influencing critical biological pathways including protein trafficking, signal transduction, and viral replication. This compound is particularly relevant for research applications in oncology, such as MYC-addicted cancers and B-cell lymphoma, as well as in the study of infectious diseases, including malaria, HIV, and rhinovirus infections.
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