NNC 05-2090 is a GABA uptake inhibitor that primarily targets the β-GABA transporter (BGT-1) with an IC50 of approximately 10.6 μM, and exhibits potent inhibition of mGAT2 with a Ki value of 1.4 μM. This compound demonstrates anticonvulsant activity, making it a valuable tool for investigating epilepsy and other neurological conditions. Its effectiveness in modulating GABA transport provides insights into potential therapeutic strategies for neurological disorders.
NNC 05-2090 is a GABA uptake inhibitor that primarily targets the β-GABA transporter (BGT-1) with an IC50 of approximately 10.6 μM, and exhibits potent inhibition of mGAT2 with a Ki value of 1.4 μM. This compound demonstrates anticonvulsant activity, making it a valuable tool for investigating epilepsy and other neurological conditions. Its effectiveness in modulating GABA transport provides insights into potential therapeutic strategies for neurological disorders.
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