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Nociceptin (1-13), amide

Catalog No.: A62440
ORL1 Receptor Agonist
Nociceptin (1-13), amide is a selective agonist of the ORL1 receptor (opioid receptor-like 1 receptor, OP4). It exhibits strong affinity, with a pEC50 value of 7.9 in mouse vas deferens assays and a binding Ki of 0.75 nM in rat forebrain membranes. This compound is valuable in studies exploring nociception, pain modulation, and potential therapeutic applications in nervous system disorders.
Nociceptin (1-13), amide 178064-02-3 ORL1 Receptor Agonist
Grouped product items
Size Price Stock Qty
5mg
$80.00
In stock
10mg
$130.00
In stock
25mg
$190.00
In stock
50mg
$280.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNociceptin (1-13), amide is a selective agonist of the ORL1 receptor (opioid receptor-like 1 receptor, OP4). It exhibits strong affinity, with a pEC50 value of 7.9 in mouse vas deferens assays and a binding Ki of 0.75 nM in rat forebrain membranes. This compound is valuable in studies exploring nociception, pain modulation, and potential therapeutic applications in nervous system disorders.
Product Information
Catalog NumA62440
FormulaC61H100N22O15
Molecular Weight1381.59
CAS Number178064-02-3
Sequence shorteningFGGFTGARKSARK-NH2
SMILESC[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O
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GPCR/G Protein > Opioid Receptors