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NoxA1ds

Catalog No.: A76904
Nox1 Inhibitor
NoxA1ds is a selective inhibitor of NADPH oxidase 1 (NOX1), with an IC50 of 20 nM. It effectively inhibits NOX1-derived superoxide production in HT-29 human colon cancer cells. Additionally, NoxA1ds reduces VEGF-induced migration of human pulmonary artery endothelial cells under hypoxic conditions in vitro. This reagent is valuable for research into hypertension, atherosclerosis, and cancer biology.
NoxA1ds 1435893-78-9 Nox1 Inhibitor
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Size Price Stock Qty
5mg
$245.00
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10mg
$405.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNoxA1ds is a selective inhibitor of NADPH oxidase 1 (NOX1), with an IC50 of 20 nM. It effectively inhibits NOX1-derived superoxide production in HT-29 human colon cancer cells. Additionally, NoxA1ds reduces VEGF-induced migration of human pulmonary artery endothelial cells under hypoxic conditions in vitro. This reagent is valuable for research into hypertension, atherosclerosis, and cancer biology.
Product Information
Catalog NumA76904
FormulaC50H88N14O15
Molecular Weight1125.32
CAS Number1435893-78-9
Sequence shorteningEPVDALGKAKV-NH2
SMILESC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)C)C(N)=O)=O)CCCCN)=O)C)=O)CCCCN)=O)=O)CC(C)C)=O)C)=O)CC(O)=O)=O)C(C)C)(=O)[C@H]1N(C([C@H](CCC(O)=O)N)=O)CCC1
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Immunology & Inflammation > NADPH oxidase