NPS-2143 (SB-262470)

Catalog No.: A11140
CaSR antagonist
NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM.
Grouped product items
Size Price Stock Qty
5mg
$40.00
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10mg
$70.00
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25mg
$150.00
In stock
50mg
$225.00
In stock
100mg
$340.00
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200mg
$580.00
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10mM * 1mL in DMSO
$45.00
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Biological Activity
Discription NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM.
Targets
Target Value
Cell Research
Cell Line Type Value Description References
Product Information
Catalog Num A11140
Formula C24H25ClN2O2
Molecular Weight 408.9
CAS Number 284035-33-2
SMILES CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O
Synonyms NPS2143, SB262470
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 79 mg/mL (193.18 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+corn oil 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.46 mL 122.28 mL 244.56 mL
0.5 mM 4.89 mL 24.46 mL 48.91 mL
1 mM 2.45 mL 12.23 mL 24.46 mL
5 mM 0.49 mL 2.45 mL 4.89 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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