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NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM.
Targets
| Ca(2+) receptor | ||||
| 43 nM |
| In vitro (25°C) | DMSO | 79 mg/mL (193.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+corn oil | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.46 mL | 122.28 mL | 244.56 mL |
| 0.5 mM | 4.89 mL | 24.46 mL | 48.91 mL |
| 1 mM | 2.45 mL | 12.23 mL | 24.46 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.89 mL |
*The above data is based on the productmolecular weight 408.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11140 |
|---|---|
| Actions | Antagonist |
| CAS No. | 284035-33-2 |
| Formula | C24H25ClN2O2 |
| M. Wt | 408.9 |
| Purity | >98% |
| Synonyms | NPS2143, SB262470 |
| SMILES | CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[[email protected]](COC3=C(C(=CC=C3)Cl)C#N)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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