NPS-2143 (SB-262470)

Catalog No.: A11140

CaSR antagonist

NPS-2143 (SB-262470) Chemical Structure

CAS NO. 284035-33-2

NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM.

Availability: In stock

Package Price Qty
10 mg
$85.00
50 mg
$350.00
100 mg
$550.00
200 mg
$900.00
10mM * 1mL in DMSO
$100.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM.
Targets
Ca(2+) receptor
43 nM
In vitro (25°C) DMSO 82 mg/mL (200.52 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.46 mL 122.28 mL 244.56 mL
0.5 mM 4.89 mL 24.46 mL 48.91 mL
1 mM 2.45 mL 12.23 mL 24.46 mL
5 mM 0.49 mL 2.45 mL 4.89 mL

*The above data is based on the productmolecular weight 408.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11140
Actions Antagonist
M. Wt 408.9
Formula C24H25ClN2O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 284035-33-2
Synonyms NPS2143, SB262470
SMILES CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[[email protected]](COC3=C(C(=CC=C3)Cl)C#N)O

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