NPS-2143 (SB-262470)

Catalog No.: A11140
CaSR antagonist
NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM.
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Product Name Price Stock Qty
NPS-2143 10mg
Special Price $68.00 Regular Price $85.00
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NPS-2143 50mg
Special Price $280.00 Regular Price $350.00
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NPS-2143 100mg
Special Price $440.00 Regular Price $550.00
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NPS-2143 200mg
Special Price $720.00 Regular Price $900.00
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NPS-2143 (SB-262470) 10mM * 1mL in DMSO
Special Price $80.00 Regular Price $100.00
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Biological Activity
Discription NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM.
Targets
Target Value
Product Information
Catalog Num A11140
Formula C24H25ClN2O2
Molecular Weight 408.9
CAS Number 284035-33-2
SMILES CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O
Synonyms NPS2143, SB262470
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 79 mg/mL (193.18 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+corn oil 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.46 mL 122.28 mL 244.56 mL
0.5 mM 4.89 mL 24.46 mL 48.91 mL
1 mM 2.45 mL 12.23 mL 24.46 mL
5 mM 0.49 mL 2.45 mL 4.89 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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