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NR1H4 activator 1

Catalog No.: A74888
FXR Activator
NR1H4 activator 1 is a highly selective agonist of the Farnesoid X Receptor (FXR), demonstrating exceptional FXR activation with an EC50 value of 1 nM in human assays. This compound has been identified for its potential therapeutic applications in gastrointestinal diseases. Its potent activity makes it a valuable tool for research focused on metabolic regulation and liver health.
NR1H4 activator 1 2242855-68-9 FXR Activator
Grouped product items
Size Price Stock Qty
25mg
$2,915.00
In stock
50mg
$3,755.00
In stock
100mg
$5,120.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNR1H4 activator 1 is a highly selective agonist of the Farnesoid X Receptor (FXR), demonstrating exceptional FXR activation with an EC50 value of 1 nM in human assays. This compound has been identified for its potential therapeutic applications in gastrointestinal diseases. Its potent activity makes it a valuable tool for research focused on metabolic regulation and liver health.
Product Information
Catalog NumA74888
FormulaC34H53NO7S
Molecular Weight619.85
CAS Number2242855-68-9
SMILESC[C@@]12[C@@H]([C@H](C)COC(NS(=O)(C3=CC=C(OC(C)C)C=C3)=O)=O)CC[C@@]1([H])[C@]4([H])[C@H](O)[C@H](CC)[C@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC2
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

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    C2

    V2

Metabolism > FXR