NS-062

Catalog No.: A28748
EGFR Inhibitor
NS-062 is an orally active, irreversible inhibitor of the epidermal growth factor receptor (EGFR). It demonstrates significant antiproliferative activity in drug-resistant double mutated H1975 cells, with an IC50 value of 0.19 μM. Furthermore, NS-062 shows antitumor efficacy in an H1975 mouse xenograft model, making it a valuable tool for research on EGFR-related cancer treatments.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNS-062 is an orally active, irreversible inhibitor of the epidermal growth factor receptor (EGFR). It demonstrates significant antiproliferative activity in drug-resistant double mutated H1975 cells, with an IC50 value of 0.19 μM. Furthermore, NS-062 shows antitumor efficacy in an H1975 mouse xenograft model, making it a valuable tool for research on EGFR-related cancer treatments.
Product Information
Catalog NumA28748
FormulaC28H30Cl2F2N6O4
Molecular Weight623.48
CAS Number2226257-92-5
SMILESFC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OCCCN4CCOCC4)=C(NC([C@H]5CCCN5C(C(Cl)F)=O)=O)C=C32
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