NS-220 is a potent and selective agonist of PPARα, exhibiting an EC50 value of 1.9 × 10^-8 M for PPARα, while demonstrating significantly lower affinity for PPARγ and PPARδ (9.6 × 10^-6 M and >10^-4 M, respectively). This compound is instrumental in research focused on hyperlipidemia and metabolic disorders associated with type-2 diabetes, aiding in the exploration of therapeutic strategies targeting lipid metabolism and glucose homeostasis.
NS-220 is a potent and selective agonist of PPARα, exhibiting an EC50 value of 1.9 × 10^-8 M for PPARα, while demonstrating significantly lower affinity for PPARγ and PPARδ (9.6 × 10^-6 M and >10^-4 M, respectively). This compound is instrumental in research focused on hyperlipidemia and metabolic disorders associated with type-2 diabetes, aiding in the exploration of therapeutic strategies targeting lipid metabolism and glucose homeostasis.
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