NSC 1008 is a selective inhibitor of Ras converting enzyme 1 (Rce1), exhibiting an in vitro IC50 of 8.9 μM in human cells. This compound demonstrates specificity for Rce1, showing minimal inhibitory effects on human Ste24 and farnesyltransferase. NSC 1008 has low cellular toxicity and effectively induces mislocalization of EGFP-Ras from the plasma membrane in cancer cells. It serves as a valuable reagent for cancer research, facilitating studies on Rce1's role in oncogenic signaling pathways.
NSC 1008 is a selective inhibitor of Ras converting enzyme 1 (Rce1), exhibiting an in vitro IC50 of 8.9 μM in human cells. This compound demonstrates specificity for Rce1, showing minimal inhibitory effects on human Ste24 and farnesyltransferase. NSC 1008 has low cellular toxicity and effectively induces mislocalization of EGFP-Ras from the plasma membrane in cancer cells. It serves as a valuable reagent for cancer research, facilitating studies on Rce1's role in oncogenic signaling pathways.
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