NSC 23766

Catalog No.: A12546

Rac1 activation inhibitor

NSC 23766

NSC 23766 Chemical Structure

CAS NO. 733767-34-5

NSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation.

Availability: In stock

Package Price Qty
10 mg
$80.00
25 mg
$150.00
50 mg
$250.00
100 mg
$400.00
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Biological Activity

NSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation.
In vitro DMSO Warmed: 92 mg/mL (173.26 mM)
Water Warmed: 92 mg/mL (173.26 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.83 mL 94.17 mL 188.33 mL
0.5 mM 3.77 mL 18.83 mL 37.67 mL
1 mM 1.88 mL 9.42 mL 18.83 mL
5 mM 0.38 mL 1.88 mL 3.77 mL

*The above data is based on the productmolecular weight 530.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12546
Actions Inhibitor
CAS No. 733767-34-5
Formula C24H35N7.3HCl
M. Wt 530.97
Solubility DMSO
Purity >98%
Synonyms NSC-23766, NSC23766
SMILES CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C2)N=C(C=C3N)C)C.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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