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NSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.83 mL | 94.17 mL | 188.33 mL |
| 0.5 mM | 3.77 mL | 18.83 mL | 37.67 mL |
| 1 mM | 1.88 mL | 9.42 mL | 18.83 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.77 mL |
*The above data is based on the productmolecular weight 530.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A12546 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 530.97 |
| Formula | C24H35N7.3HCl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 733767-34-5 |
| Synonyms | NSC-23766, NSC23766 |
| SMILES | CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C2)N=C(C=C3N)C)C.Cl |
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