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Biological Activity
NSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation.
| In vitro | DMSO | Warmed: 92 mg/mL (173.26 mM) | |
| Water | Warmed: 92 mg/mL (173.26 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.72 mL | 118.6 mL | 237.19 mL |
| 0.5 mM | 4.74 mL | 23.72 mL | 47.44 mL |
| 1 mM | 2.37 mL | 11.86 mL | 23.72 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
*The above data is based on the productmolecular weight 421.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12546 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 733767-34-5 |
| Formula | C24H35N7 |
| M. Wt | 421.6 |
| Purity | >98% |
| Synonyms | NSC-23766, NSC23766 |
| SMILES | CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C(N=C3C=C2)C)N)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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