NSC 23766

Catalog No.: A12546
Rac1 activation inhibitor
NSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation.
Grouped product items
Product Name Price Stock Qty
NSC 23766 10mg
$80.00
In stock
NSC 23766 25mg
$150.00
In stock
NSC 23766 50mg
$250.00
In stock
NSC 23766 100mg
$400.00
In stock
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Biological Activity
Discription NSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation.
Product Information
Catalog Num A12546
Formula C24H35N7
Molecular Weight 421.6
CAS Number 733767-34-5
SMILES CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C(N=C3C=C2)C)N)C
Synonyms NSC-23766, NSC23766
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO Warmed: 92 mg/mL (173.26 mM)
Water Warmed: 92 mg/mL (173.26 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.72 mL 118.6 mL 237.19 mL
0.5 mM 4.74 mL 23.72 mL 47.44 mL
1 mM 2.37 mL 11.86 mL 23.72 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
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