nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2), exhibiting an IC50 value of 0.13 ± 0.06 μM. This compound demonstrates metabolic stability in liver microsomes and possesses a favorable brain-to-plasma ratio, making it suitable for studies involving central nervous system diseases. nSMase2-IN-1 is a valuable reagent for research applications focused on elucidating the role of sphingolipid metabolism in neurological disorders.
nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2), exhibiting an IC50 value of 0.13 ± 0.06 μM. This compound demonstrates metabolic stability in liver microsomes and possesses a favorable brain-to-plasma ratio, making it suitable for studies involving central nervous system diseases. nSMase2-IN-1 is a valuable reagent for research applications focused on elucidating the role of sphingolipid metabolism in neurological disorders.
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