Nurr1/RXR Agonist 1 is a dual agonist that specifically targets the Nurr1 receptor (EC50 = 2.6 µM) and retinoid X receptor (RXR) with affinity constants of 0.6 and 1.1 µM, respectively. This compound selectively activates the DR5 response element by destabilizing the Nurr1 homodimer while stabilizing the Nurr1:RXR heterodimer. Nurr1/RXR Agonist 1 promotes the expression of neuroprotective target genes while minimizing off-target effects in neuronal cells. This reagent is suitable for research in neurodegenerative diseases.
Nurr1/RXR Agonist 1 is a dual agonist that specifically targets the Nurr1 receptor (EC50 = 2.6 µM) and retinoid X receptor (RXR) with affinity constants of 0.6 and 1.1 µM, respectively. This compound selectively activates the DR5 response element by destabilizing the Nurr1 homodimer while stabilizing the Nurr1:RXR heterodimer. Nurr1/RXR Agonist 1 promotes the expression of neuroprotective target genes while minimizing off-target effects in neuronal cells. This reagent is suitable for research in neurodegenerative diseases.
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