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NVP-AEW541 dihydrochloride

Catalog No.: A33768
IGF-1R Inhibitor
NVP-AEW541 dihydrochloride is a potent inhibitor of the insulin-like growth factor 1 receptor (IGF-1R), exhibiting an IC50 value of 0.15 μM. This compound also demonstrates inhibition of the insulin receptor (InsR) with an IC50 value of 0.14 μM. NVP-AEW541 dihydrochloride is recognized for its antitumor activity, making it a valuable tool for cancer research and therapeutic investigations targeting IGF signaling pathways.
NVP-AEW541 dihydrochloride 2320261-63-8 IGF-1R Inhibitor
Grouped product items
Size Price Stock Qty
500µg
$230.00
In stock
1mg
$340.00
In stock
5mg
$1,295.00
In stock
10mg
$2,320.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNVP-AEW541 dihydrochloride is a potent inhibitor of the insulin-like growth factor 1 receptor (IGF-1R), exhibiting an IC50 value of 0.15 μM. This compound also demonstrates inhibition of the insulin receptor (InsR) with an IC50 value of 0.14 μM. NVP-AEW541 dihydrochloride is recognized for its antitumor activity, making it a valuable tool for cancer research and therapeutic investigations targeting IGF signaling pathways.
Product Information
Catalog NumA33768
FormulaC27H31Cl2N5O
Molecular Weight512.47
CAS Number2320261-63-8
SMILES[H]Cl.[H]Cl.NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
SynonymsAEW541 dihydrochloride
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Protein Tyrosine Kinases > IGF-1R