Signaling Pathway
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| Discription | NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively). | |||||
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| Cell Research |
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| Catalog Num | A11021 |
|---|---|
| Formula | C27H29N5O |
| Molecular Weight | 439.6 |
| CAS Number | 475489-16-8 |
| SMILES | C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6 |
| Synonyms | AEW541 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 77 mg/mL (175.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 19 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.75 mL | 113.74 mL | 227.48 mL |
| 0.5 mM | 4.55 mL | 22.75 mL | 45.5 mL |
| 1 mM | 2.27 mL | 11.37 mL | 22.75 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.55 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
