NVP-AEW541

Catalog No.: A11021

IGF-1R inhibitor

NVP-AEW541 Chemical Structure

CAS NO. 475489-16-8

NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).

Availability: In stock

Package Price Qty
2 mg
$80.00
5 mg
$120.00
10 mg
$150.00
25 mg
$300.00
10mM * 1mL in DMSO
$110.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).
In vitro (25°C) DMSO 88 mg/mL (200.2 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.75 mL 113.74 mL 227.48 mL
0.5 mM 4.55 mL 22.75 mL 45.5 mL
1 mM 2.27 mL 11.37 mL 22.75 mL
5 mM 0.45 mL 2.27 mL 4.55 mL

*The above data is based on the productmolecular weight 439.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11021
Actions Inhibitor
M. Wt 439.6
Formula C27H29N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 475489-16-8
Synonyms AEW541
SMILES C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6

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