NVP-AEW541

Name: NVP-AEW541
Brand: Adooq Bioscience
SKU: A11021
Rating: 100 (1 reviews)

Catalog No.: A11021

IGF-1R inhibitor

Product Citations (1)

NVP-AEW541 Chemical Structure

CAS NO. 475489-16-8

NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).

Availability: In stock

Package	Price	Qty
2 mg	Regular Price: $80.00 Special Price $64.00
5 mg	Regular Price: $120.00 Special Price $96.00
10 mg	Regular Price: $150.00 Special Price $120.00
25 mg	Regular Price: $300.00 Special Price $240.00
10mM * 1mL in DMSO	Regular Price: $110.00 Special Price $88.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq NVP-AEW541

Tsushima H, .et al. Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis, Autoimmunity, 2017, Aug;50(5):329-335 PMID: 28682648

Biological Activity

Solubility *

In vitro (25°C)	DMSO	77 mg/mL (175.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.75 mL	113.74 mL	227.48 mL
0.5 mM	4.55 mL	22.75 mL	45.5 mL
1 mM	2.27 mL	11.37 mL	22.75 mL
5 mM	0.45 mL	2.27 mL	4.55 mL

*The above data is based on the productmolecular weight 439.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11021
Actions	Inhibitor
CAS No.	475489-16-8
Formula	C27H29N5O
M. Wt	439.6
Purity	>98%
Synonyms	AEW541
SMILES	C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.