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- Tsushima H, .et al. Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis, Autoimmunity, 2017, Aug;50(5):329-335 PMID: 28682648
Biological Activity
NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).
| In vitro (25°C) | DMSO | 77 mg/mL (175.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 19 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.75 mL | 113.74 mL | 227.48 mL |
| 0.5 mM | 4.55 mL | 22.75 mL | 45.5 mL |
| 1 mM | 2.27 mL | 11.37 mL | 22.75 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.55 mL |
*The above data is based on the productmolecular weight 439.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11021 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 475489-16-8 |
| Formula | C27H29N5O |
| M. Wt | 439.6 |
| Purity | >98% |
| Synonyms | AEW541 |
| SMILES | C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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