BGJ398 (NVP-BGJ398)

Catalog No.: A11159

FGFR Inhibitor

BGJ398 (NVP-BGJ398) Chemical Structure

CAS NO. 872511-34-7

BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively).

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$70.00
50 mg
$140.00
100 mg
$240.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively).
Targets
Target Value
FGFR1IC50: 0.9nM
FGFR3IC50: 1.0nM
FGFR2IC50: 1.4nM
FGFR3(K650E)IC50: 4.9nM
FGFR4IC50: 60nM
VEGFR2IC50: 0.18μM
LynIC50: 0.30μM
KitIC50: 0.75μM
YESIC50: 1.1μM
FynIC50: 1.9μM
AblIC50: 2.3μM
LCKIC50: 2.5μM
In vitro (25°C) DMSO 1 mg/mL heating (1.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.84 mL 89.21 mL 178.42 mL
0.5 mM 3.57 mL 17.84 mL 35.68 mL
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

*The above data is based on the productmolecular weight 560.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11159
Actions Inhibitor
M. Wt 560.48
Formula C26H31Cl2N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 872511-34-7
Synonyms BGJ-398
SMILES CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl

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