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EphB4 inhibitor

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Catalog No. A10661

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
NVP-BHG712 5mg A10661-5

Regular Price: $80.00

Special Price: $72.00

NVP-BHG712 10mg A10661-10

Regular Price: $150.00

Special Price: $135.00

NVP-BHG712 50mg A10661-50

Regular Price: $700.00

Special Price: $630.00

NVP-BHG712 100mg A10661-100

Regular Price: $1,200.00

Special Price: $1,080.00

NVP-BHG712 10mM * 1mL in DMSO A10661-10mM-D

Regular Price: $140.00

Special Price: $126.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.


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Publications citing Adooq Products
NVP-BHG712 Citations (1)
  • Y Kaibori, .et al. EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity, the FASEB Journal, 2019, Jan 22:fj201801519RR PMID: 30668924

Chemical Information

Catalog Num A10661
Actions Inhibitor
M. Wt 503.5
Formula C26H20F3N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 940310-85-0
Synonyms NVPBHG712

Biological Activity

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
Target Value
C-RafIC50: 0.395μM
c-SrcIC50: 1.266μM
c-AblIC50: 1.667μM
Tie-2IC50: >10μM
AxlIC50: >10μM
HER1IC50: >10μM
PKAIC50: >10μM
CDK1IC50: >10μM
PKBIC50: >10μM
PDK-1IC50: >10μM
FGFR3IC50: >10μM
c-MetIC50: >10μM


Solubility (25°C) * In vitro DMSO 101 mg/mL (200.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (5.95 mM)
In vivo NMP/polyethylene glycol 300 (10/90, v/v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.86 mL 99.3 mL 198.61mL
0.5 mM 3.97 mL 19.86 mL 39.72 mL
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL

*The above data is based on the productmolecular weight 503.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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