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Catalog No.: A10661

EphB4 inhibitor


NVP-BHG712 Chemical Structure

CAS NO. 940310-85-0

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.

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5 mg

Regular Price: $80.00

Special Price $64.00

10 mg

Regular Price: $150.00

Special Price $120.00

50 mg

Regular Price: $600.00

Special Price $480.00

100 mg

Regular Price: $1,000.00

Special Price $800.00

10mM * 1mL in DMSO

Regular Price: $120.00

Special Price $96.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Y Kaibori, .et al. EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity, the FASEB Journal, 2019, Jan 22:fj201801519RR PMID: 30668924

Biological Activity

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
Target Value
C-RafIC50: 0.395μM
c-SrcIC50: 1.266μM
c-AblIC50: 1.667μM
Tie-2IC50: >10μM
AxlIC50: >10μM
HER1IC50: >10μM
PKAIC50: >10μM
CDK1IC50: >10μM
PKBIC50: >10μM
PDK-1IC50: >10μM
FGFR3IC50: >10μM
c-MetIC50: >10μM
In vitro (25°C) DMSO 90 mg/mL (178.75 mM)
Water Insoluble
Ethanol 3 mg/mL (5.95 mM)
In vivo NMP+PEG300 (10+90, v+v) 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.86 mL 99.3 mL 198.61 mL
0.5 mM 3.97 mL 19.86 mL 39.72 mL
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL

*The above data is based on the productmolecular weight 503.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10661
Actions Inhibitor
CAS No. 940310-85-0
Formula C26H20F3N7O
M. Wt 503.5
Purity >98%
Synonyms NVPBHG712

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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