- Y Kaibori, .et al. EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity, the FASEB Journal, 2019, Jan 22:fj201801519RR PMID: 30668924
Biological Activity
NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
Targets
Target | Value | |
---|---|---|
EphB4 | ED50 | 25nM |
C-Raf | IC50: 0.395μM | |
c-Src | IC50: 1.266μM | |
c-Abl | IC50: 1.667μM | |
Tie-2 | IC50: >10μM | |
Axl | IC50: >10μM | |
HER1 | IC50: >10μM | |
PKA | IC50: >10μM | |
CDK1 | IC50: >10μM | |
PKB | IC50: >10μM | |
PDK-1 | IC50: >10μM | |
FGFR3 | IC50: >10μM | |
c-Met | IC50: >10μM |
In vitro (25°C) | DMSO | 101 mg/mL (200.6 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | 3 mg/mL (5.95 mM) | ||
In vivo | NMP/polyethylene glycol 300 (10/90, v/v) | 30 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.86 mL | 99.3 mL | 198.61 mL |
0.5 mM | 3.97 mL | 19.86 mL | 39.72 mL |
1 mM | 1.99 mL | 9.93 mL | 19.86 mL |
5 mM | 0.4 mL | 1.99 mL | 3.97 mL |
*The above data is based on the productmolecular weight 503.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10661 |
---|---|
Actions | Inhibitor |
M. Wt | 503.5 |
Formula | C26H20F3N7O |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 940310-85-0 |
Synonyms | NVPBHG712 |
SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5 |
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