NVP-BHG712

Catalog No.: A10661

EphB4 inhibitor

NVP-BHG712 Chemical Structure

CAS NO. 940310-85-0

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$150.00
50 mg
$600.00
100 mg
$1,000.00
10mM * 1mL in DMSO
$120.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
Targets
Target Value
EphB4ED5025nM
C-RafIC50: 0.395μM
c-SrcIC50: 1.266μM
c-AblIC50: 1.667μM
Tie-2IC50: >10μM
AxlIC50: >10μM
HER1IC50: >10μM
PKAIC50: >10μM
CDK1IC50: >10μM
PKBIC50: >10μM
PDK-1IC50: >10μM
FGFR3IC50: >10μM
c-MetIC50: >10μM
In vitro (25°C) DMSO 101 mg/mL (200.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (5.95 mM)
In vivo NMP/polyethylene glycol 300 (10/90, v/v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.86 mL 99.3 mL 198.61 mL
0.5 mM 3.97 mL 19.86 mL 39.72 mL
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL

*The above data is based on the productmolecular weight 503.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10661
Actions Inhibitor
M. Wt 503.5
Formula C26H20F3N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 940310-85-0
Synonyms NVPBHG712
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5

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