OBHSA is a selective estrogen receptor alpha (ERα) degrader that facilitates the degradation of cyclin D1, effectively bypassing resistance to Tamoxifen. By inducing an increase in intracellular reactive oxygen species, OBHSA activates the unfolded protein response (UPR) excessively, leading to apoptosis in susceptible cells. Additionally, OBHSA serves as an ERα ligand for the synthesis of PROTAC degraders, making it a valuable tool in the study of ERα-mediated pathways and therapeutic resistance in cancer research.
OBHSA is a selective estrogen receptor alpha (ERα) degrader that facilitates the degradation of cyclin D1, effectively bypassing resistance to Tamoxifen. By inducing an increase in intracellular reactive oxygen species, OBHSA activates the unfolded protein response (UPR) excessively, leading to apoptosis in susceptible cells. Additionally, OBHSA serves as an ERα ligand for the synthesis of PROTAC degraders, making it a valuable tool in the study of ERα-mediated pathways and therapeutic resistance in cancer research.
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