Obtusin is a selective and competitive inhibitor of human monoamine oxidase-A (hMAO-A) with an IC50 of 11.12 μM and a Ki of 6.15 μM. Isolated from the seeds of Cassia obtusifolia Linn, Obtusin demonstrates potential neuroprotective effects, making it relevant for research into neurodegenerative diseases, particularly those associated with anxiety and depression. Its ability to inhibit hMAO-A may contribute to the modulation of serotonin and norepinephrine levels, offering a valuable tool for elucidating mechanisms underlying mood disorders.
Obtusin is a selective and competitive inhibitor of human monoamine oxidase-A (hMAO-A) with an IC50 of 11.12 μM and a Ki of 6.15 μM. Isolated from the seeds of Cassia obtusifolia Linn, Obtusin demonstrates potential neuroprotective effects, making it relevant for research into neurodegenerative diseases, particularly those associated with anxiety and depression. Its ability to inhibit hMAO-A may contribute to the modulation of serotonin and norepinephrine levels, offering a valuable tool for elucidating mechanisms underlying mood disorders.
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