Olaparib-d5 is a deuterated version of Olaparib, a potent and orally active inhibitor of the poly (ADP-ribose) polymerases PARP1 and PARP2, exhibiting IC50 values of 5 nM and 1 nM, respectively. This stable isotope is valuable for pharmacokinetic and metabolic studies, enabling precise tracking of Olaparib metabolism in biological systems. Additionally, Olaparib has been shown to activate autophagy and mitophagy, thereby contributing to its therapeutic efficacy in cancer research.
Olaparib-d5 is a deuterated version of Olaparib, a potent and orally active inhibitor of the poly (ADP-ribose) polymerases PARP1 and PARP2, exhibiting IC50 values of 5 nM and 1 nM, respectively. This stable isotope is valuable for pharmacokinetic and metabolic studies, enabling precise tracking of Olaparib metabolism in biological systems. Additionally, Olaparib has been shown to activate autophagy and mitophagy, thereby contributing to its therapeutic efficacy in cancer research.
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