Opakalim is a selective activator of Kv7.2 and Kv7.3 potassium channels, exhibiting an EC50 of 0.6 μM. It demonstrates minimal activation of GABAA receptors while offering potent anti-seizure efficacy in the maximal electroshock seizure (MES) model. Opakalim is suitable for research applications focused on seizure mechanisms and the modulation of neuronal excitability.
Opakalim is a selective activator of Kv7.2 and Kv7.3 potassium channels, exhibiting an EC50 of 0.6 μM. It demonstrates minimal activation of GABAA receptors while offering potent anti-seizure efficacy in the maximal electroshock seizure (MES) model. Opakalim is suitable for research applications focused on seizure mechanisms and the modulation of neuronal excitability.
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