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Org 20599 methanesulfonate

Catalog No.: A66842
GABAA Agonist
Org 20599 methanesulfonate is a selective agonist of the GABAA receptor, exhibiting an EC50 value of 1.1 μM. This compound plays a significant role in modulating inhibitory neurotransmission and is valuable for studying neurological disorders and related mechanisms. Its potent activity provides insights into the therapeutic potential of GABAA receptor modulation in various neurological contexts.
Org 20599 methanesulfonate 187652-71-7 GABAA Agonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionOrg 20599 methanesulfonate is a selective agonist of the GABAA receptor, exhibiting an EC50 value of 1.1 μM. This compound plays a significant role in modulating inhibitory neurotransmission and is valuable for studying neurological disorders and related mechanisms. Its potent activity provides insights into the therapeutic potential of GABAA receptor modulation in various neurological contexts.
Product Information
Catalog NumA66842
FormulaC26H44ClNO6S
Molecular Weight534.15
CAS Number187652-71-7
SMILESCS(=O)(O)=O.C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@@H]([C@@H](N4CCOCC4)C2)O)([H])[C@@]5([H])[C@](CC3)([C@H](CC5)C(CCl)=O)C
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

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Neuronal Signaling > GABA Receptors