Oritinib mesylate is a selective, orally active irreversible inhibitor of the epidermal growth factor receptor (EGFR) with an IC50 of 18 nM. This compound demonstrates strong activity against both EGFR-sensitive and T790M-resistant mutations. Oritinib mesylate effectively inhibits the proliferation of tumor cells harboring these mutations, making it a valuable tool for research in cancer biology and targeted therapies.
Oritinib mesylate is a selective, orally active irreversible inhibitor of the epidermal growth factor receptor (EGFR) with an IC50 of 18 nM. This compound demonstrates strong activity against both EGFR-sensitive and T790M-resistant mutations. Oritinib mesylate effectively inhibits the proliferation of tumor cells harboring these mutations, making it a valuable tool for research in cancer biology and targeted therapies.
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