OSI-420

Catalog No.: A10678
EGFR Inhibitor
OSI-420 (Desmethyl Erlotinib,CP-473420) is an orally active EGFR tyrosin kinase inhibitor, which inhibits receptor tyrosine kinases (TKs) by inhibition of the intercellular domain .
Grouped product items
Product Name Price Stock Qty
OSI-420 5mg
$110.00
In stock
OSI-420 10mg
$200.00
In stock
OSI-420 50mg
$520.00
In stock
OSI-420 100mg
$920.00
In stock
OSI-420 10mM * 1mL in DMSO
$120.00
In stock
Bulk Size
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's OSI-420 has been cited by 2 publications
  • Yuta Yamamoto, .et al. , J Pharm Anal, 2018, Apr; 8(2): 119-123 PMID: 29736298
  • Janet L. Martin, .et al. , Breast Cancer Res, 2017, 19: 90 PMID: 28778177
  • Biological Activity
    Discription OSI-420 (Desmethyl Erlotinib,CP-473420) is an orally active EGFR tyrosin kinase inhibitor, which inhibits receptor tyrosine kinases (TKs) by inhibition of the intercellular domain .
    Targets
    Target Value
    Product Information
    Catalog Num A10678
    Formula C21H21N3O4.HCl
    Molecular Weight 415.9
    CAS Number 183320-51-6
    SMILES COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO.Cl
    Synonyms Desmethyl Erlotinib,CP-473420
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO Warmed: 75 mg/mL (180.34 mM)
    Water Insoluble
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.04 mL 120.22 mL 240.44 mL
    0.5 mM 4.81 mL 24.04 mL 48.09 mL
    1 mM 2.4 mL 12.02 mL 24.04 mL
    5 mM 0.48 mL 2.4 mL 4.81 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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