Osimertinib-13C,d3 is a stable isotope-labeled derivative of Osimertinib, a covalent, orally active, irreversible inhibitor of mutant-selective EGFR. This compound exhibits an apparent IC50 value of 12 nM against the L858R mutation and 1 nM against the L858R/T790M mutation. Osimertinib-13C,d3 is essential for analytical studies, including pharmacokinetics and metabolic profiling, enabling researchers to investigate the drug's biological activity and mechanism of action in various cancer research applications.
Osimertinib-13C,d3 is a stable isotope-labeled derivative of Osimertinib, a covalent, orally active, irreversible inhibitor of mutant-selective EGFR. This compound exhibits an apparent IC50 value of 12 nM against the L858R mutation and 1 nM against the L858R/T790M mutation. Osimertinib-13C,d3 is essential for analytical studies, including pharmacokinetics and metabolic profiling, enabling researchers to investigate the drug's biological activity and mechanism of action in various cancer research applications.
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