OTX015

Catalog No.: A13890

BET inhibitor

OTX015

OTX015 Chemical Structure

CAS NO. 202590-98-5

OTX015 is an orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50s = 10-19 nM).

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$90.00
25 mg
$180.00
50 mg
$250.00
10mM * 1mL in DMSO
$130.00
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Biological Activity

OTX015 is an orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50s = 10-19 nM).
Targets
BRDs (Cell-free assay)
10-19 nM(EC50)
In vitro (25°C) DMSO 89 mg/mL (180.9 mM)
Water Insoluble
Ethanol 89 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.33 mL 101.63 mL 203.26 mL
0.5 mM 4.07 mL 20.33 mL 40.65 mL
1 mM 2.03 mL 10.16 mL 20.33 mL
5 mM 0.41 mL 2.03 mL 4.07 mL

*The above data is based on the productmolecular weight 491.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13890
Actions Inhibitor
CAS No. 202590-98-5
Formula C25H22ClN5O2S
M. Wt 491.99
Purity >98%
Synonyms OTX 015, OTX-015
SMILES CC1=C(SC2=C1C(=N[[email protected]](C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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