P-CAB Agent 2 is a potent potassium-competitive acid blocker that targets and inhibits H+/K+-ATPase activity, demonstrating an IC50 of less than 100 nM. It is effective in reducing gastric acid secretion and shows no acute toxicity. Additionally, P-CAB Agent 2 inhibits the hERG potassium channel with an IC50 of 18.69 µM, making it relevant for studies in gastric physiology and potential therapeutic applications for acid-related disorders.
P-CAB Agent 2 is a potent potassium-competitive acid blocker that targets and inhibits H+/K+-ATPase activity, demonstrating an IC50 of less than 100 nM. It is effective in reducing gastric acid secretion and shows no acute toxicity. Additionally, P-CAB Agent 2 inhibits the hERG potassium channel with an IC50 of 18.69 µM, making it relevant for studies in gastric physiology and potential therapeutic applications for acid-related disorders.
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