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Catalog No.: A13547

CDK Inhibitor


P276-00 Chemical Structure

CAS NO. 920113-03-7

P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3

Availability: In stock

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5 mg
10 mg
25 mg
10mM * 1mL in DMSO
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Biological Activity

P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3
Target Value
CDK9/CyclinT1IC50: 20nM
CDK4/CyclinD1IC50: 63nM
CDK1/CyclinBIC50: 79nM
CDK2/CyclinAIC50: 224nM
CDK6/CyclinD3IC50: 396nM
CDK2/CyclinEIC50: 2.54μM
GSK-3βIC50: 2.771μM
CDK7/CyclinHIC50: 2.87μM
c-SrcIC50: <10μM
PKCαIC50: 10μM
MAPK1IC50: 22μM
PKCIC50: 25μM
MAPK2IC50: >100μM
PKAIC50: 575μM
In vitro (25°C) DMSO 79 mg/mL (180.24 mM)
Water 79 mg/mL (180.24 mM)
Ethanol 6 mg/mL (13.69 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.82 mL 114.08 mL 228.15 mL
0.5 mM 4.56 mL 22.82 mL 45.63 mL
1 mM 2.28 mL 11.41 mL 22.82 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13547
Actions Inhibitor
CAS No. 920113-03-7
Formula C21H20ClNO5.HCl
M. Wt 438.3
Purity >98%
Synonyms P276, P276-00
SMILES CN1CC[[email protected]]([[email protected]@H]1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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