P2Y14R antagonist 4

Catalog No.: A36084
P2Y14R Antagonist
P2Y14R Antagonist 4 is a potent oral antagonist of the P2Y14 receptor, exhibiting an IC50 value of 5.6 nM, indicating high binding affinity. This compound demonstrates anti-inflammatory activity by effectively reducing the release of proinflammatory cytokines, such as IL-1β, IL-6, and TNF-α, in response to LPS stimulation. P2Y14R Antagonist 4 is valuable for research applications in inflammation and immune response modulation.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionP2Y14R Antagonist 4 is a potent oral antagonist of the P2Y14 receptor, exhibiting an IC50 value of 5.6 nM, indicating high binding affinity. This compound demonstrates anti-inflammatory activity by effectively reducing the release of proinflammatory cytokines, such as IL-1β, IL-6, and TNF-α, in response to LPS stimulation. P2Y14R Antagonist 4 is valuable for research applications in inflammation and immune response modulation.
Product Information
Catalog NumA36084
FormulaC27H27F3N2O4S
Molecular Weight532.57
CAS Number3081687-67-1
SMILESOC(C1=CC(C2=CC=C(C3CCNCC3)C=C2)=CC(NS(CCC4=CC=C(C(F)(F)F)C=C4)(=O)=O)=C1)=O
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