(-)-P7C3-S243 is an orally bioavailable neuroprotective agent that effectively crosses the blood-brain barrier. This compound primarily binds to the μ-opioid receptor and translocator protein (TSPO), demonstrating the ability to inhibit premature apoptosis in newborn hippocampal neurons while safeguarding mature nigral dopaminergic neurons. (-)-P7C3-S243 not only promotes neuronal survival but also mitigates cognitive impairments and alleviates depression-like behaviors in rat models. It is a valuable tool for research focused on neurodegenerative diseases such as Parkinson's and Alzheimer's disease.
(-)-P7C3-S243 is an orally bioavailable neuroprotective agent that effectively crosses the blood-brain barrier. This compound primarily binds to the μ-opioid receptor and translocator protein (TSPO), demonstrating the ability to inhibit premature apoptosis in newborn hippocampal neurons while safeguarding mature nigral dopaminergic neurons. (-)-P7C3-S243 not only promotes neuronal survival but also mitigates cognitive impairments and alleviates depression-like behaviors in rat models. It is a valuable tool for research focused on neurodegenerative diseases such as Parkinson's and Alzheimer's disease.
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