Pazopanib-d3 is a deuterium-labeled derivative of Pazopanib, a multi-target tyrosine kinase inhibitor. Pazopanib primarily inhibits vascular endothelial growth factor receptors (VEGFR1, VEGFR2, VEGFR3) and platelet-derived growth factor receptor beta (PDGFRβ), alongside c-Kit, fibroblast growth factor receptor 1 (FGFR1), and c-Fms, exhibiting IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM, respectively. This stable isotope-labeled compound is particularly useful for metabolic studies and pharmacokinetic analyses in cancer research applications.
Pazopanib-d3 is a deuterium-labeled derivative of Pazopanib, a multi-target tyrosine kinase inhibitor. Pazopanib primarily inhibits vascular endothelial growth factor receptors (VEGFR1, VEGFR2, VEGFR3) and platelet-derived growth factor receptor beta (PDGFRβ), alongside c-Kit, fibroblast growth factor receptor 1 (FGFR1), and c-Fms, exhibiting IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM, respectively. This stable isotope-labeled compound is particularly useful for metabolic studies and pharmacokinetic analyses in cancer research applications.
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