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Pazopanib-d3

Stable Isotope

Pazopanib-d3 is a deuterium-labeled derivative of Pazopanib, a multi-target tyrosine kinase inhibitor. Pazopanib primarily inhibits vascular endothelial growth factor receptors (VEGFR1, VEGFR2, VEGFR3) and platelet-derived growth factor receptor beta (PDGFRβ), alongside c-Kit, fibroblast growth factor receptor 1 (FGFR1), and c-Fms, exhibiting IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM, respectively. This stable isotope-labeled compound is particularly useful for metabolic studies and pharmacokinetic analyses in cancer research applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1219591-97-5
Applications	Stable Isotope
Formula	C₂₁H₂₀D₃N₇O₂S
Molecular Weight	440.54
Synonyms	GW786034-d3
SMILES	O=S(C1=CC(NC2=NC=CC(N(C3=CC4=NN(C(C)=C4C=C3)C)C([2H])([2H])[2H])=N2)=CC=C1C)(N)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.