PCI-32765 (Ibrutinib)

Catalog No.: A11020
Bruton tyrosine kinase inhibitor
PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
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Product Name Price Stock Qty
PCI-32765 10mg
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PCI-32765 25mg
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PCI-32765 100mg
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PCI-32765 10mM * 1mL in DMSO
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Adooq Products cited in reputable paper
Adooq's PCI-32765 (Ibrutinib) has been cited by 5 publications
  • Marta G Fuster, .et al. , Pharmaceutics, 2023, Apr 7;15(4):1186 PMID: 37111671
  • Simonowski A, .et al. , Biochim Biophys Acta Mol Cell Res, 2019, Dec 11;1867(4):118622 PMID: 31837347
  • Carolin N. Zorn, .et al. , Sci Rep, 2018, 8: 15467 PMID: 30341350
  • Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Biological Activity
    Discription PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
    Target Value
    Product Information
    Catalog Num A11020
    Formula C25H24N6O2
    Molecular Weight 440.5
    CAS Number 936563-96-1
    SMILES C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N
    Synonyms Ibrutinib

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO 81 mg/mL (183.88 mM)
    Water Insoluble
    Ethanol 41 mg/mL (93.07 mM)
    In vivo 5% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.7 mL 113.51 mL 227.01 mL
    0.5 mM 4.54 mL 22.7 mL 45.4 mL
    1 mM 2.27 mL 11.35 mL 22.7 mL
    5 mM 0.45 mL 2.27 mL 4.54 mL
    Useful Calculator

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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