Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Simonowski A, .et al. Differential use of BTK and PLC in FcεRI- and KIT-mediated mast cell activation: A marginal role of BTK upon KIT activation, Biochim Biophys Acta Mol Cell Res, 2019, Dec 11;1867(4):118622 PMID: 31837347
- Carolin N. Zorn, .et al. Stimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells, Sci Rep, 2018, 8: 15467 PMID: 30341350
- Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
- Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277 A
Biological Activity
PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
Targets
Target | Value |
---|---|
BTK | IC50: 0.5nM |
BLK | IC50: 0.5nM |
Bmx | IC50: 0.8nM |
CSK | IC50: 2.3nM |
FGR | IC50: 2.3nM |
BRK | IC50: 3.3nM |
Hck | IC50: 3.7nM |
EGFR | IC50: 5.6nM |
YES | IC50: 6.5nM |
ErbB2 | IC50: 9.4nM |
ITK | IC50: 10.7nM |
JAK3 | IC50: 16.1nM |
FRK | IC50: 29.2nM |
LCK | IC50: 33.2nM |
RET | IC50: 36.5nM |
FLT3 | IC50: 73nM |
TEC | IC50: 78nM |
Abl | IC50: 86nM |
Fyn | IC50: 96nM |
RIPK2 | IC50: 152nM |
c-Src | IC50: 171nM |
Lyn | IC50: 200nM |
PDGFRα | IC50: 718nM |
Fms | IC50: 5.545μM |
FER | IC50: 8.07μM |
JAK1 | IC50: >10μM |
JAK2 | IC50: >10μM |
NEK2 | IC50: >10μM |
p38 | IC50: >10μM |
PI3K | IC50: >10μM |
PLK1 | IC50: >10μM |
RSK1 | IC50: >10μM |
Syk | IC50: >10μM |
In vitro (25°C) | DMSO | 81 mg/mL (183.88 mM) | |
Water | Insoluble | ||
Ethanol | 41 mg/mL (93.07 mM) | ||
In vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O | 9 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.7 mL | 113.51 mL | 227.01 mL |
0.5 mM | 4.54 mL | 22.7 mL | 45.4 mL |
1 mM | 2.27 mL | 11.35 mL | 22.7 mL |
5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
*The above data is based on the productmolecular weight 440.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11020 |
---|---|
Actions | Inhibitor |
CAS No. | 936563-96-1 |
Formula | C25H24N6O2 |
M. Wt | 440.5 |
Purity | >98% |
Synonyms | Ibrutinib |
SMILES | C=CC(=O)N1CCC[[email protected]](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy PCI-32765 (Ibrutinib) | PCI-32765 (Ibrutinib) Supplier | purchase | cost | manufacturer | order | distributor | buy 936563-96-1| 936563-96-1 Supplier | purchase 936563-96-1 | 936563-96-1 cost | 936563-96-1 manufacturer | order 936563-96-1 | 936563-96-1 distributor