PCI-32765 (Ibrutinib)

Catalog No.: A11020
Bruton tyrosine kinase inhibitor
PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
Grouped product items
Size Price Stock Qty
5mg
$30.00
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10mg
$40.00
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25mg
$45.00
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50mg
$50.00
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100mg
$65.00
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200mg
$85.00
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500mg
$180.00
In stock
10mM * 1mL in DMSO
$40.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's PCI-32765 (Ibrutinib) has been cited by 6 publications
  • Daniel Tarnowski, .et al. , Front Cardiovasc Med, 2023, Aug 15:10:119009 PMID: 37655217
  • Marta G Fuster, .et al. , Pharmaceutics, 2023, Apr 7;15(4):1186 PMID: 37111671
  • Simonowski A, .et al. , Biochim Biophys Acta Mol Cell Res, 2019, Dec 11;1867(4):118622 PMID: 31837347
  • Carolin N. Zorn, .et al. , Sci Rep, 2018, 8: 15467 PMID: 30341350
  • Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Biological Activity
    Discription PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    Product Information
    Catalog Num A11020
    Formula C25H24N6O2
    Molecular Weight 440.5
    CAS Number 936563-96-1
    SMILES C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N
    Synonyms Ibrutinib
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 81 mg/mL (183.88 mM)
    Water Insoluble
    Ethanol 41 mg/mL (93.07 mM)
    In vivo 5% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.7 mL 113.51 mL 227.01 mL
    0.5 mM 4.54 mL 22.7 mL 45.4 mL
    1 mM 2.27 mL 11.35 mL 22.7 mL
    5 mM 0.45 mL 2.27 mL 4.54 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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