PD176252

Catalog No.: A19385

BB1/BB2 antagonist

PD176252

PD176252 Chemical Structure

CAS NO. 204067-01-6

PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.

Availability: In stock

Package Price Qty
2 mg
$120.00
5 mg
$200.00
10 mg
$360.00
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Biological Activity

PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.1 mL 85.52 mL 171.04 mL
0.5 mM 3.42 mL 17.1 mL 34.21 mL
1 mM 1.71 mL 8.55 mL 17.1 mL
5 mM 0.34 mL 1.71 mL 3.42 mL

*The above data is based on the productmolecular weight 584.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19385
Actions Antagonist
CAS No. 204067-01-6
Formula C32H36N6O5
M. Wt 584.67
Purity >98%
Synonyms PD 176252, PD-176252
SMILES O=C(NC1=CC=C([N+]([O-])=O)C=C1)N[[email protected]](CC2=CNC3=C2C=CC=C3)(C)C(NCC4(C5=CC=C(OC)C=N5)CCCCC4)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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