PDE1-IN-11 is a potent and selective inhibitor of phosphodiesterase 1A1 (PDE1A1). This compound enhances intracellular levels of cAMP and cGMP, thereby activating the PKA-CREB and NO-cGMP-PKG signaling pathways, which in turn promotes osteoblast differentiation and supports bone formation while inhibiting osteoclastogenesis and bone resorption. PDE1-IN-11 is a valuable tool for investigating postmenopausal osteoporosis and other disorders related to bone metabolism.
PDE1-IN-11 is a potent and selective inhibitor of phosphodiesterase 1A1 (PDE1A1). This compound enhances intracellular levels of cAMP and cGMP, thereby activating the PKA-CREB and NO-cGMP-PKG signaling pathways, which in turn promotes osteoblast differentiation and supports bone formation while inhibiting osteoclastogenesis and bone resorption. PDE1-IN-11 is a valuable tool for investigating postmenopausal osteoporosis and other disorders related to bone metabolism.
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