PDE1-IN-5 is a selective inhibitor of phosphodiesterase 1C (PDE1C), exhibiting an IC50 value of 15 nM. This compound demonstrates significant anti-inflammatory activity by reducing the expression of key pro-inflammatory cytokines, including iNOS, TNF-α, IL-1α, IL-1β, and IL-6 in response to LPS stimulation. PDE1-IN-5 has been shown to mitigate symptoms associated with inflammatory bowel disease (IBD) in the dextran sodium sulfate (DSS)-induced colitis mouse model, making it a valuable tool for research in IBD mechanisms and therapies.
PDE1-IN-5 is a selective inhibitor of phosphodiesterase 1C (PDE1C), exhibiting an IC50 value of 15 nM. This compound demonstrates significant anti-inflammatory activity by reducing the expression of key pro-inflammatory cytokines, including iNOS, TNF-α, IL-1α, IL-1β, and IL-6 in response to LPS stimulation. PDE1-IN-5 has been shown to mitigate symptoms associated with inflammatory bowel disease (IBD) in the dextran sodium sulfate (DSS)-induced colitis mouse model, making it a valuable tool for research in IBD mechanisms and therapies.
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