PDE3/4-IN-3 is a potent dual inhibitor of phosphodiesterase 3 and 4, exhibiting IC50 values of 0.17 nM for PDE3A and ≤50 nM for PDE4B2. This compound effectively reduces methacholine-induced bronchoconstriction in guinea pigs, demonstrating its potential in respiratory research. PDE3/4-IN-3 is valuable for investigating therapeutic strategies in chronic obstructive pulmonary disease (COPD) and asthma.
PDE3/4-IN-3 is a potent dual inhibitor of phosphodiesterase 3 and 4, exhibiting IC50 values of 0.17 nM for PDE3A and ≤50 nM for PDE4B2. This compound effectively reduces methacholine-induced bronchoconstriction in guinea pigs, demonstrating its potential in respiratory research. PDE3/4-IN-3 is valuable for investigating therapeutic strategies in chronic obstructive pulmonary disease (COPD) and asthma.
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