PDE4-IN-12 is a potent pan-PDE4 inhibitor that demonstrates IC50 values of 3.5 nM for PDE4 and 15 nM for PDE7, with selectivity indices of 2.71 and 4.27, respectively. This compound is well-tolerated and is suitable for research applications in the study of inflammatory bowel diseases (IBDs) and related inflammatory conditions. Its strong inhibitory activity on phosphodiesterase enzymes makes it a valuable tool for investigating therapeutic strategies in inflammatory disorders.
PDE4-IN-12 is a potent pan-PDE4 inhibitor that demonstrates IC50 values of 3.5 nM for PDE4 and 15 nM for PDE7, with selectivity indices of 2.71 and 4.27, respectively. This compound is well-tolerated and is suitable for research applications in the study of inflammatory bowel diseases (IBDs) and related inflammatory conditions. Its strong inhibitory activity on phosphodiesterase enzymes makes it a valuable tool for investigating therapeutic strategies in inflammatory disorders.
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