PDE4-IN-9 is a potent inhibitor of phosphodiesterase 4 (PDE4) exhibiting an IC50 value of 1.4 μM, which is lower than that of the parent compound rolipram (2.0 μM) in in vitro enzyme assays. This compound demonstrates significant biological activity in vivo, effectively modulating inflammatory responses in animal models of asthma, chronic obstructive pulmonary disease (COPD), and sepsis induced by lipopolysaccharide (LPS). PDE4-IN-9 is a valuable tool for researching therapeutic approaches to managing inflammatory diseases.
PDE4-IN-9 is a potent inhibitor of phosphodiesterase 4 (PDE4) exhibiting an IC50 value of 1.4 μM, which is lower than that of the parent compound rolipram (2.0 μM) in in vitro enzyme assays. This compound demonstrates significant biological activity in vivo, effectively modulating inflammatory responses in animal models of asthma, chronic obstructive pulmonary disease (COPD), and sepsis induced by lipopolysaccharide (LPS). PDE4-IN-9 is a valuable tool for researching therapeutic approaches to managing inflammatory diseases.
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