PDE5-IN-1 is a potent phosphodiesterase 5 (PDE5) inhibitor with an IC50 of 5.6 nM and notable oral bioavailability. It interacts with the catalytic domain of PDE5 through hydrogen bonds with the Q817 residue and π-π stacking with the F820 residue. PDE5-IN-1 demonstrates significant anti-cardiac hypertrophy and vasodilatory effects, effectively lowering mean pulmonary arterial pressure and right ventricular hypertrophy index. This compound is valuable for research focused on pulmonary arterial hypertension.
PDE5-IN-1 is a potent phosphodiesterase 5 (PDE5) inhibitor with an IC50 of 5.6 nM and notable oral bioavailability. It interacts with the catalytic domain of PDE5 through hydrogen bonds with the Q817 residue and π-π stacking with the F820 residue. PDE5-IN-1 demonstrates significant anti-cardiac hypertrophy and vasodilatory effects, effectively lowering mean pulmonary arterial pressure and right ventricular hypertrophy index. This compound is valuable for research focused on pulmonary arterial hypertension.
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