PDZ1 Domain inhibitor peptide

Catalog No.: A67130
GluR6/PSD-95 Inhibitor
PDZ1 Domain Inhibitor Peptide is a cyclic peptide designed to specifically target the PDZ1 domains of postsynaptic density protein 95 (PSD-95). By disrupting the interaction between GluR6 and PSD-95, this inhibitor effectively competes with the C terminus of GluR6 for binding to the PDZ1 domain. Its unique β-Ala lactam side chain linker enhances its efficacy in studies related to synaptic signaling and glutamate receptor regulation. This reagent is ideal for research applications focusing on neuronal communication and synaptic plasticity.
Grouped product items
Size Price Stock Qty
1mg
$30.00
In stock
5mg
$150.00
In stock
10mg
$235.00
In stock
Bulk Size
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
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Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
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Biological Activity
DescriptionPDZ1 Domain Inhibitor Peptide is a cyclic peptide designed to specifically target the PDZ1 domains of postsynaptic density protein 95 (PSD-95). By disrupting the interaction between GluR6 and PSD-95, this inhibitor effectively competes with the C terminus of GluR6 for binding to the PDZ1 domain. Its unique β-Ala lactam side chain linker enhances its efficacy in studies related to synaptic signaling and glutamate receptor regulation. This reagent is ideal for research applications focusing on neuronal communication and synaptic plasticity.
Product Information
Catalog NumA67130
FormulaC38H61N9O11
Molecular Weight819.94
CAS Number1315378-73-4
SequenceTyr-Lys-Lys-Thr-Glu-Ala-Val (Lactam bridge:Lys3-Glu5)
Sequence shorteningYKKTEAV (Lactam bridge:Lys3-Glu5)
SMILESN(C([C@@H](NC([C@H](CC1=CC=C(O)C=C1)N)=O)CCCCN)=O)[C@@H]2C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)C)=O)CCC(=O)NCCCC2)[H]
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